2017 APR 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Nutritional and Metabolic Diseases and Conditions - Obesity are presented in a new report. According to news reporting from Ramat Gan, Israel, by NewsRx journalists, research stated, "Maternal obesity is a risk factor for offspring obesity. Melanocortin 4 receptor (Mc4r) is one of the mediators of food intake and energy balance."
The news correspondents obtained a quote from the research from Bar-Ilan University, "This study examines epigenetic mechanisms underlying altered Mc4r levels in the hypothalamic paraventricular nucleus in offspring of high-fat diet (HFD)-induced obese dams, and aims to elucidate the role of thyroid hormones in epigenetic regulation and tagging of their nucleosome at the Mc4r promoter. Female Wistar rats were fed HFD or chow from weaning through gestation and lactation. Epigenetic alterations were analyzed in the offspring on postnatal day 21 at the Mc4r promoter using chromatin immunoprecipitation and bisulfite sequencing. To study T3's role in Mc4r downregulation, dams received methimazole (MMI), an inhibitor of thyroid hormone production. Offspring of HFD-fed dams had higher body weight, elevated plasma T3 concentrations and lower Mc4r mRNA levels than controls. At the Mc4r promoter, offspring of HFD-fed mothers demonstrated increased histone 3 lysine 27 acetylation (H3K27ac) with higher association to TRb, an inhibitor of Mc4r transcription. Moreover, TRb co-immunoprecipitated with H3K27ac, supporting their presence in the same complex. Maternal MMI administration prevented the HFD-reduction in Mc4r levels, the increase in TRb and the increase in TRb-H3K27ac association, providing further support for T3's role in downregulating Mc4r levels."
According to the news reporters, the research concluded: "These findings demonstrate that a perinatal HFD environment affects Mc4r regulation through a T3 metabolic pathway involving histone acetylation of its promoter."
For more information on this research see: Thyroid hormone-dependent epigenetic regulation of melanocortin 4 receptor levels in female offspring of obese rats. Endocrinology, 2017;():. (The Endocrine Society - www.endo-society.org/; Endocrinology - endo.endojournals.org/)
Our news journalists report that additional information may be obtained by contacting T. Tabachnik, Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel. Additional authors for this research include T. Kisliouk, A. Marco, N. Meiri and A. Weller.
Keywords for this news article include: Asia, Israel, Obesity, Genetics, Ramat Gan, Bariatrics, Neuropeptides, Peptide Hormones, Peptide Proteins, Thyroid Hormones, Pituitary Hormones, Risk and Prevention, Pro Opiomelanocortin, Nerve Tissue Proteins, Nutritional and Metabolic Diseases and Conditions.
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