Increase of blood glucose continuing challenge of public health, and increase of mortality values. Several evidences suggest that antioxidants consumption decreased hyperglycemia. In this study, we compared the effect of garlic extract and gliclazide on blood glucose level in STZ-induced diabetic mice. In this study, five male mice groups (n=10 for each group) used. Control group (group 1) received normal saline and four groups received STZ (40 mg/kg). One group received STZ only, and three next group consumed garlic extract, gliclazide and garlic extract+gliclazide for one month. After one month, glucose concentration was measured. In diabetic group glucose concentration was significantly increased (p Key words: Hyperglycemia, Garlic Extract, Gliclazide, Mice.
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