INCIDENCE OF DIABETIC EYE DISEASE IN ACCORDANCE WITH DURATION, GLYCEMIC CONTROL, BLOOD AND OCULAR PRESSURE/INCIDENCIJA DIJABETESNE BOLESTI OKA U ODNOSU NA TRAJANJE BOLESTI, KONTROLU GLIKEMIJE, KRVNI I OCNI PRITISAK

Citation metadata

Authors: Vladimir Canadanovic, Sandra Jovanovic, Sofija Davidovic, Ana Oros, Vladislav Dzinic and Sava Barisic
Date: November-December 2017
From: Medicinski Pregled(Vol. 70, Issue 11-12)
Publisher: Drustvo Lekara Vojvodine
Document Type: Report
Length: 3,809 words

Main content

Abstract :

Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness among professionally active adults in economically developed societies, which is of particular concern because the prevalence and incidence of diabetes mellitus is expected to increase sharply during the next decade. There are several known factors responsible for the development of diabetic retinopathy, duration of disease and blood sugar level being the most important ones. Material and Methods. Prospective study of 280 diabetic patients (diabetes mellitus type 2) divided into 3 groups according to the duration of diabetes mellitus. All diabetic patients underwent complete ophthalmological examination in artificial mydriasis and optic coherence tomography. A full medical history included patient age, the time elapsed from diabetes diagnosis, current treatment of diabetes, presence of hypertension and glycemic control assessed by glycosylated hemoglobin measurement. Results. The mean age of patients was 63.5 years (SD[+ or -]6.5, range 57-70 years). Mean duration of diabetes was 7.3 years in group I, 12.4 years in group II and 17.2 years in group III. The average value of glycosylated hemoglobin was 6.58% in the group I, 7.64% in the group II and 8.29% in the third group of patients. No statistically significant difference in intraocular pressure and the level of blood pressure were found among groups. Cataract was present in 104 patients (37.1%). Complications related to diabetes among all patients included in our study were: nonproliferative diabetic retinopathy in 48.5%, proliferative diabetic retinopathy in 25.7% and diabetic macular edema in 22.5% of patients. Conclusion. The duration of diabetes is one of the most significant factors for the development of diabetic maculopathy and the progression from nonproliferative to its proliferative stage. There is significantly higher incidence of proliferative diabetic retinopathy and diabetic macular edema in patients with increased serum level of glycosylated hemoglobin. Diabetes accompanied by hypertension is related to worsening of the clinical course of diabetic eye diseases and developing diabetic macular edema and proliferative diabetic retinopathy. Key words: Diabetic Retinopathy; Macular Edema; Cataract; Diabetes Complications; Diabetes Mellitus, Type 2; Blood Glucose; Intraocular Pressure; Hemoglobin A, Glycosylated; Hypertension Sazetak Uvod. Dijabetesna retinopatija je i dalje vodeci uzrok pada vidne ostrine i slepila medu radno aktivnom populacijom u ekonomski razvijenim drustvima, sto je od posebnog znacaja ako se uzme u obzir da se ocekuje povecan broj obolelih od secerne bolesti u sledecoj deceniji. Poznato je nekoliko faktora odgovornih za razvoj dijabetesne retiniopatije, od kojih su najvazniji duzina trajanja bolesti i visina glikemije. Materijal i metode. Ova studija je bila prospektivnog tipa sa 280 pacijenata koji boluju od secerne bolesti (tip 2), podeljenih u tri grupe u zavisnosti od duzine trajanja bolesti. Svi pacijenti koji boluju od dijabetesa podvrgnuti su kompletnom oftalmoloskom pregledu u artificijelnoj midrijazi i snimanju optickom koherentnom tomografijom. Evidentirana je celokupna istorija bolesti koja je ukljucivala starost pacijenta, vreme proteklo od postavljanja dijagnoze secerne bolesti, trenutnu terapiju, prisustvo arterijske hipertenzije, kao i stepen kontrole glikemije procenjena merenjem vrednosti glikoliziranog hemoglobina. Rezultati. Prosecna starost pacijenata iznosila je 63,5 godina (SD [+ or -] 6,5). Prosecna duzina trajanja secerne boelsti iznosila je 7,3 godine u prvoj grupi, 12,4 godine u drugoj grupi i 17,2 godine u trecoj grupi. Prosecna vrednost glikoliziranog hemoglobina bila je 6,58% u prvoj grupi, 7,76% u drugoj grupi, dok je ona iznosila 8,29% u trecoj grupi pacijenata. Nije ustanovljena statisticki znacajna razlika izmedu ispitivanih grupa u visini intraokularnog pritiska i visini krvnog pritiska. Katarakta je bila prisutna kod 104 pacijenta (37,1%). Ucestalost komplikacija u vezi sa dijabetesom medu ispitivanim pacijentima iznosila je: neproliferativna dijabetesna retinopatija kod 48,5%, proliferativna dijabetesna retinopatija kod 25,7%, a dijabetesni makularni edem kod 22,5% pacijenata. Zakljucak. Duzina trajanja secerne bolesti je jedan od najvaznijih faktora rizika za razvoj dijabetesne makulopatije i progresije neproliferativne u proliferativnu formu dijabeticke retinopatije. Ustanovljena je statisticki znacajno veca incidencija proliferativne dijabetesne retinopatije i dijabetesnog makularnog edema kod pacijenata sa povisenom koncentracijom glikoliziranog hemoglobina u serumu. Dijabetes udruzen sa arterijskom hipertenzijom povezan je sa pogorsanjem klinickog toka bolesti oka i sa razvojem dijabetesnog makularnog edema i proliferativne dijabetesne retinopatije. Kljucne reci: dijabetesna retinopatija; makularni edem; katarakta; komplikacije dijabetesa; dijabetes melitus tip 2; glikemija; intraokularni pritisak; glikozilizirani hemoglobin; hipertenzija

Source Citation

Source Citation
Canadanovic, Vladimir, et al. "INCIDENCE OF DIABETIC EYE DISEASE IN ACCORDANCE WITH DURATION, GLYCEMIC CONTROL, BLOOD AND OCULAR PRESSURE/INCIDENCIJA DIJABETESNE BOLESTI OKA U ODNOSU NA TRAJANJE BOLESTI, KONTROLU GLIKEMIJE, KRVNI I OCNI PRITISAK." Medicinski Pregled, vol. 70, no. 11-12, Nov.-Dec. 2017, pp. 353+. Accessed 25 Sept. 2021.
  

Gale Document Number: GALE|A531467565