Byline: Muhammad Ajaib, Taha Arooj, Khalid Mohammed Khan, Sidra Farid, Muhammad Ishtiaq, Shahnaz Perveen and Shazia Shah
Summary: The present study was conducted to evaluate phytochemicals, antimicrobial and antioxidant potential of Lagerstroemia indica L. The phytochemical screening of L. indica revealed the presence of active metabolites such as anthraquinones, reducing sugars, terpenoids, flavonoids, saponins, tannins, alkaloids and cardiac glycosides. Antimicrobial assessment was carried out against Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungal strains (Aspergillus oryzae and Aspergillus niger). Maximum antibacterial potential (58.33 0.88 mm) was exhibited by petroleum ether extract of bark against B. subtilis. The maximum antifungal potential 40.33 0.88 mm and 40.0 1.15 mm against A. niger was observed by chloroform extract of bark and fruits respectively. The antioxidant potential was assessed using five assays viz.
ABTS activity, DPPH radical scavenging activity, metal chelating activity, total flavonoid contents and total phenolic contents. Highest TEAC value 7.946 0.04 mM trolox for ABTS+ assay was observed by aquous extract of leaves. The highest values for total flavonoid contents 1185.740 0.01 ug/ml and total phenolic contents 40.333 0.23 ug/ml was exhibited by petroleum ether bark extract. The maximum metal chelating activity 60.302 0.93 was observed by petroleum ether extract of fruit. The highest value of % DPPH (92.92 0.08 %) was observed by aquous extract of bark.
Key words: Phytochemicals, Lagerstroemia indica L., Antimicrobial, Antioxidant, MIC
Herbal medicine, also known as botanical medicine or phytomedicine refers to using plant seeds, flowers, roots for medicinal purpose. It is very important to improve analysis and quality control along with advances in clinical research to show the value of herbal medicine in treating and preventing disease . Demand of drugs to obtained from plant sources is increasing day by day, which can only be fulfilled by screening medicinal plants with promising biological activity. In developing countries, medicines are quite expensive, so there is a need of investigation of the antimicrobial activity of ethnomedicinal plants . The development of drug resistance in human pathogens against commonly used antibiotics has necessitated a search for new antimicrobial substances from other sources, including plants. Plants used in traditional medicines contain a wide range of substances that are used to treat chronic as well as infectious diseases .
Lagerstroemia indica L belongs to family lythraceae. It is commonly known as "Crape myrtle". It is a perennial shrub and reaches at the height of 10 to 30 feet and spreads 10 to 15 feet. It showed many biological activities such as anti- inflammatory, antipyretic, analgesic, antihyperglycemic, antioxidant, hepatoprotective and antihyperglycemical . Previously diterpenoids, triterpenoids, sterols,  anthocyanins ; lignans , alkaloids  fatty acids  sesquiterpenes and coumarins  were reported from different species of Lagerstroemia.
The present study was designed to investigate the antimicrobial and antioxidant activities of an ethnobotanically important plant Lagerstroemia indica L.
Chemicals and Reagents
All chemicals and reagents were used of the standard grade. Petroleum ether (C2H5OC2H5), chloroform (CHCl3), methanol (CH3OH), distilled water (H2O), ferric chloride,...
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