Skin rejuvenation with autologous concentrated platelet-rich plasma

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Authors: Nancy Mikhael and Fatma El-Esawy
Date: January-June 2014
From: Egyptian Journal of Dermatology and Venerology(Vol. 34, Issue 1)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Report
Length: 2,743 words

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Byline: Nancy. Mikhael, Fatma. El-Esawy

Objective The aim of this study was to assess the efficacy of autologous platelet-rich plasma (PRP) injection for facial rejuvenation. Patients and methods In a 6-month study, 20 female patients were treated with three sessions of injection with PRP every month from October 2011 to March 2012. Patients received 3 ml of PRP, activated with calcium chloride into face and neck skin. The study was evaluated by comparing the preinjection and postinjection photographs using digital camera, by final patient's satisfaction questionnaire, and by physician's impression. Results A definitive graduated score was found for each patient by adding the final result of each single parameter. Good results were observed in the skin homogeneity and emotional status of the patient without serious side effects. Conclusion PRP had an effective treatment in skin rejuvenation without serious side effects.


Platelet-rich plasma (PRP) can be defined as 'an autologous concentration of human platelets in a small volume of plasma'. This concentrate contains the trophic growth factors that are released once the platelets therein are activated either by calcium chloride, thrombin, or fibrinogen. All seem to be equally effective in activating the platelets [1]. PRP has long been known as an effective treatment in various surgical and medical fields. Face and neck revitalization with PRP is an application that is being explored [2].

Facial rejuvenation utilizing autologous platelet growth factors, such as platelet-derived growth factor, transforming-growth factor, vascular endothelial growth factor, insulin-like growth factor, and epidermal growth factor, is a natural approach to restore dermal degeneration [3].

Autologous PRP offers regarding facial rejuvenation: quantifiable improvement of skin complexion was observed with visible changes noticeable in 3-4 weeks, especially forehead, cheeks, neck, and back of hands; it is not a volumetric filler but a biological cell therapy with patient's own cells and a popular, relatively painless injectable treatment for the aging face in cosmetic practices [4].

Aim of work

The aim of the study was to evaluate the autologous PRP injection for facial rejuvenation, to assess the final patients' satisfaction, and to assess whether there is any side effect.

Patients and methods

This study was carried out in the Dermatology and Venereology Department, Faculty of Medicine, Benha University Hospitals from October 2011 to March 2012. Twenty healthy female patients with different types of facial wrinkles were enrolled in this study and treated with one session of injections with PRP every month (a total of three sessions); their age ranged from 30 to 55 years with Fitzpatrick skin types III to V.

History was taken from each patient including personal history, present history, family history, history of drug intake, irradiation, chemotherapy, history of previous treatment, cosmetic surgery, allergy to previous treatment, and sun exposure. Clinical and dermatological examination was performed.

Exclusion criteria included:

*Facial cancer, past and present; *Patients using systemic chemotherapy, anticoagulation therapy, or steroid; *Dermatological diseases affecting the face; *Blood disorders and platelet abnormalities; *The use of any herbal products; *Patient on aspirin or antiplatelet agents; and *Systemic diseases including...

Source Citation

Source Citation
Mikhael, Nancy, and Fatma El-Esawy. "Skin rejuvenation with autologous concentrated platelet-rich plasma." Egyptian Journal of Dermatology and Venerology, vol. 34, no. 1, Jan.-June 2014, p. 5. Accessed 27 Sept. 2022.

Gale Document Number: GALE|A394559851