Study data from J. Pujol and colleagues update understanding of life sciences

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Date: June 30, 2009
Publisher: NewsRX LLC
Document Type: Brief article
Length: 385 words
Lexile Measure: 1400L

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Scientists discuss in 'Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety' new findings in life sciences. "Social anxiety often involves a combination of hypervigilance and avoidance to potentially warning signals including the facial expression of emotions. Functional imaging has demonstrated an increase in amygdala response to emotional faces in subjects with social anxiety," investigators in Barcelona, Spain report (see also Life Sciences).

"Nevertheless, it is unclear to what extent visual areas processing faces influence amygdala reactivity in different socially anxious individuals. We assessed the influence of the fusiform gyrus activation on amygdala response to emotional faces in the non-clinical range of social anxiety. Twenty-two normal subjects showing a wide range in social anxiety scores were examined using functional magnetic resonance imaging (fMRI) during the processing of happy and fearful faces. A dimensional analysis approach was used involving voxel-wise mapping of the correlation between subjects' social anxiety scores and amygdala activation, before and after controlling for fusiform gyrus activation. We observed that only after controlling for subjects' level of activation of the fusiform gyrus was there an association between social anxiety ratings and amygdala response to both happy and fearful faces. The fusiform gyrus influence was more robust during the fear condition. Of note, fusiform gyrus response to fearful faces showed a negative correlation with additional behavioral assessments related to avoidance, including social anxiety scores, harm avoidance and sensitivity to punishment. Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety that may ultimately attenuate amygdala responses," wrote J. Pujol and colleagues, .

The researchers concluded: "Future research will help to establish the role of this effect in a clinical context."

Pujol and colleagues published their study in Psychological Medicine (Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychological Medicine, 2009;39(7):1177-87).

For additional information, contact J. Pujol, Institut d'Alta Tecnologia-PRBB, Dept. of Magnetic Resonance, CRC Corporacio Sanitaria, Barcelona, Spain.

The publisher of the journal Psychological Medicine can be contacted at: Cambridge University Press, 32 Avenue of the Americas, New York, NY 10013-2473.

Keywords: Spain, Barcelona, Life Sciences, Psychology, Mental Health, Magnetic Resonance.

This article was prepared by Science Letter editors from staff and other reports. Copyright 2009, Science Letter via

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Gale Document Number: GALE|A202892461